Group list Animal models-
*Monkeys, dogs, pigs are used as animal models they are used by creating heart attacks, heart failure, abnormal heart rhythms, strokes, and other cardiovascular traumas. [1]
*dogs whose coronary artery had been ligated demonstrated by applying an electric current to the heart of a dog it showed that the activity in the muscle was independent of the nervous system. [2]
*The zebrafish - which can mend its own heart muscle - is providing clues to heart failure. They are fully functioning, and have a simple heart and circulatory system that is easy to study because they are semi-transparent. Fibroblast growth factor (Fgf) – may be the evolutionary switch that triggered four-chambered human hearts, from the two-chambered ‘tube-heart’ found in fish. [3]
*Dahl/Salt Sensitive Rat-diastolic heart failure Inbred from a congenic control group of Dahl/SS rats [4]
*SHHF Rat-heart failure were developed by backcrossing the SHROB rat to the SHR/N rat. [4]
*SHRSP Rat-stroke developed by backcrossing the SHROB rat to the SHR/N rat. [4]
APA~
1-Society, G. E. (2009, December 06). Animals in Science / Research. Retrieved April 11, 2017, from http://www.neavs.org/research/biomedical#sourcesSociety
2-MacWilliam JA. (1887) "Fibrillar contraction of the heart." J Physiol. Retrieved April 11, 2017, from http://www.animalresearch.info/en/medical-advances/diseases-research/cardiac-arrest-ventricular-fibrillation/
3-S., M. (2014, November 19). Heart Disease and Zebra Fish. Retrieved April 11, 2017, from http://www.understandinganimalresearch.org.uk/why/human-health/heart-disease-and-zebrafish/
4-Labatory, C. R. (2017). Find a Model. Retrieved April 11, 2017, from http://www.criver.com/find-a-model?therapeutic_area=Cardiovascular
*Monkeys, dogs, pigs are used as animal models they are used by creating heart attacks, heart failure, abnormal heart rhythms, strokes, and other cardiovascular traumas. [1]
*dogs whose coronary artery had been ligated demonstrated by applying an electric current to the heart of a dog it showed that the activity in the muscle was independent of the nervous system. [2]
*The zebrafish - which can mend its own heart muscle - is providing clues to heart failure. They are fully functioning, and have a simple heart and circulatory system that is easy to study because they are semi-transparent. Fibroblast growth factor (Fgf) – may be the evolutionary switch that triggered four-chambered human hearts, from the two-chambered ‘tube-heart’ found in fish. [3]
*Dahl/Salt Sensitive Rat-diastolic heart failure Inbred from a congenic control group of Dahl/SS rats [4]
*SHHF Rat-heart failure were developed by backcrossing the SHROB rat to the SHR/N rat. [4]
*SHRSP Rat-stroke developed by backcrossing the SHROB rat to the SHR/N rat. [4]
APA~
1-Society, G. E. (2009, December 06). Animals in Science / Research. Retrieved April 11, 2017, from http://www.neavs.org/research/biomedical#sourcesSociety
2-MacWilliam JA. (1887) "Fibrillar contraction of the heart." J Physiol. Retrieved April 11, 2017, from http://www.animalresearch.info/en/medical-advances/diseases-research/cardiac-arrest-ventricular-fibrillation/
3-S., M. (2014, November 19). Heart Disease and Zebra Fish. Retrieved April 11, 2017, from http://www.understandinganimalresearch.org.uk/why/human-health/heart-disease-and-zebrafish/
4-Labatory, C. R. (2017). Find a Model. Retrieved April 11, 2017, from http://www.criver.com/find-a-model?therapeutic_area=Cardiovascular
Delcy Lopez Garcia-
Dogs were a great animal model for heart disease in 1954 because they were tested with shocks to see how the heart functions. Dogs helped contribute to the defibrillator, and it has a come a long way and developed into something more complex. Animal research made an enormous contribution to the invention and subsequent constant improvement of the defibrillator. The success of scientist in preventing deaths in cases of sudden cardiac arrest has since led to the installation of defibrillation machines in airports, railway stations and sports centers. This installation was great because of the dogs providing a great model in research for ventricular disorders. Ventricular fibrillation is form of cardiac arrest where the muscles of the heart contract in an uncoordinated way, and fail to pump blood around the body. It often occurs as a consequence of a heart attack.
Research, A. (2016). Cardiac arrest & ventricular fibrillation. Retrieved April 11, 2017, from http://www.animalresearch.info/en/medical-advances/diseases-research/cardiac-arrest-ventricular-fibrillation/
Dogs were a great animal model for heart disease in 1954 because they were tested with shocks to see how the heart functions. Dogs helped contribute to the defibrillator, and it has a come a long way and developed into something more complex. Animal research made an enormous contribution to the invention and subsequent constant improvement of the defibrillator. The success of scientist in preventing deaths in cases of sudden cardiac arrest has since led to the installation of defibrillation machines in airports, railway stations and sports centers. This installation was great because of the dogs providing a great model in research for ventricular disorders. Ventricular fibrillation is form of cardiac arrest where the muscles of the heart contract in an uncoordinated way, and fail to pump blood around the body. It often occurs as a consequence of a heart attack.
Research, A. (2016). Cardiac arrest & ventricular fibrillation. Retrieved April 11, 2017, from http://www.animalresearch.info/en/medical-advances/diseases-research/cardiac-arrest-ventricular-fibrillation/
Talal A.
Rodents have become widely used as models of cardiovascular diseases such as atherosclerosis and heart failure. In one prominent example, research in a rat model of heart failure led to the widespread clinical use of angiotensin-converting enzyme (ACE) inhibitors in the aftermath of heart attacks, a practice that decreases mortality by as much as 19 percent over the four years following a heart attack. In addition, after a new statin drug was shown in rats to block an enzyme associated with high cholesterol, it went on to become the widely popular cholesterol-lowering drug Crestor, which garnered 22.5 monthly prescriptions in 2014.
Rodent research is creating an exciting horizon for cardiovascular disease treatment. Recent research with rats and mice has alerted scientists to the possibility of using growth factors and stem cells to regenerate cardiac tissue after a heart attack. Mouse research has also highlighted a promising future treatment for atherosclerosis — a molecule that lowers cholesterol levels in the blood and dissolves artery-clogging plaques by mimicking the body’s “good” cholesterol.
Society, N. E. (n.d.). Animals in Science / Research. Retrieved April 12, 2017, from http://www.neavs.org/research/biomedical
http://www.nabr.org/
Rodents have become widely used as models of cardiovascular diseases such as atherosclerosis and heart failure. In one prominent example, research in a rat model of heart failure led to the widespread clinical use of angiotensin-converting enzyme (ACE) inhibitors in the aftermath of heart attacks, a practice that decreases mortality by as much as 19 percent over the four years following a heart attack. In addition, after a new statin drug was shown in rats to block an enzyme associated with high cholesterol, it went on to become the widely popular cholesterol-lowering drug Crestor, which garnered 22.5 monthly prescriptions in 2014.
Rodent research is creating an exciting horizon for cardiovascular disease treatment. Recent research with rats and mice has alerted scientists to the possibility of using growth factors and stem cells to regenerate cardiac tissue after a heart attack. Mouse research has also highlighted a promising future treatment for atherosclerosis — a molecule that lowers cholesterol levels in the blood and dissolves artery-clogging plaques by mimicking the body’s “good” cholesterol.
Society, N. E. (n.d.). Animals in Science / Research. Retrieved April 12, 2017, from http://www.neavs.org/research/biomedical
http://www.nabr.org/
Elliot Y.
Prof. Dr. Gilbert Weidinger and his team of researchers at the Institute for Biochemistry and Molecular Biology at the University of Ulm are exploring the regenerative mechanisms of the zebrafish heart. The fish are popular model organisms for biologists because the relatively big embryos are transparent. This makes it possible to follow developmental processes pretty easley. The ability of the zebrafish to regenerate damaged organs is cool. So if the heart was damaged with heart diseases the zebrafish can help heal its self and heal the heart. “This is what makes zebrafish so interesting for us and we want to find out why they have this ability while mammals do not,” says Weidinger “To be more specific, we are looking for genes that control the cell division process during regeneration. If we knew the factors and were able to activate them in human beings, we would potentially be able to regenerate human cardiomyocytes. But this is still a pipe dream. We still know far too little about the animals’ regenerative ability. Nevertheless, this is the basic idea behind our research.”
Neis-Beeckmann, D. P. (2016, March 29). Healthcare industry. Retrieved April 12, 2017, from https://www.gesundheitsindustrie-bw.de/en/article/news/the-zebrafish-can-mend-its-own-heart/
Prof. Dr. Gilbert Weidinger and his team of researchers at the Institute for Biochemistry and Molecular Biology at the University of Ulm are exploring the regenerative mechanisms of the zebrafish heart. The fish are popular model organisms for biologists because the relatively big embryos are transparent. This makes it possible to follow developmental processes pretty easley. The ability of the zebrafish to regenerate damaged organs is cool. So if the heart was damaged with heart diseases the zebrafish can help heal its self and heal the heart. “This is what makes zebrafish so interesting for us and we want to find out why they have this ability while mammals do not,” says Weidinger “To be more specific, we are looking for genes that control the cell division process during regeneration. If we knew the factors and were able to activate them in human beings, we would potentially be able to regenerate human cardiomyocytes. But this is still a pipe dream. We still know far too little about the animals’ regenerative ability. Nevertheless, this is the basic idea behind our research.”
Neis-Beeckmann, D. P. (2016, March 29). Healthcare industry. Retrieved April 12, 2017, from https://www.gesundheitsindustrie-bw.de/en/article/news/the-zebrafish-can-mend-its-own-heart/